Brian Plouffe

Brian Plouffe

E-mail:
Department: Chemical Engineering
Advisor: Shashi Murthy

Collaborators: Sri Sridhar

Biography

IGERT_photo

Ph.D. Chemical Engineering, May 2011
Northeastern University

M.S. Chemical Engineering, May 2007
Northeastern University

B.S. Chemical Engineering, May 2004
University of Rhode Island

Lab website:www.microfluidicslab.org

Projects

Presentations

  • Poster Presentation: Design And Validation Of A Novel Endothelial Progenitor Cell Capture Chip And Its Application In Patients With Pulmonary Arterial Hypertension, G. Hansmann, B.D. Plouffe, A. Hatch, A.von Gise, H. Sallmon, R.T. Zamanian, and S.K. Murthy, 2011 Pediatric Academic Societies and Asian Society for Pediatric Research Joint Meeting, Denver, CO, May 2011
  • Oral Presentation: Isolation of Rare-cell Populations via a Rationally Designed Microfluidic Magnetophoresis Device, B.D. Plouffe (speaker), L.H. Lewis, and S.K. Murthy, MRS Spring Meeting, San Francisco, CA, Apr 2011
  • Oral Presentation: Microfluidic Endothelial Progenitor Cell Capture for Point-of-Care Cardiovascular Diagnostics, B.D. Plouffe (speaker), G. Hansmann, A. Hatch, A. von Gise, H. Sallmon, R.T. Zamanian and S.K. Murthy, MRS Spring Meeting, San Francisco, CA, Apr 2011
  • Poster Presentation:Isolation of Rare-Cell Populations via a Rationally Designed Microfluidic Magnetophoresis Device, B.D. Plouffe, L.H. Lewis, and S.K. Murthy , 2011 Northeastern Research and Scholarship Expo, Boston, MA (Outstanding Graduate Student Research Award), Apr 2011
  • Poster Presentation: Microfluidic Endothelial Progenitor Cell Capture Technology for Cardiovascular Diagnostic Medicine, B.D. Plouffe, A. Hatch, G. Hansmann, and S. K. Murthy, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2010), Groningen, Netherlands, Oct 2010
  • Oral Presentation: Towards Cell Capture and Isolation: Derivation and Modeling of Forces on a Magnetically Labeled Cell Within a Microfluidic Device Design, B. D. Plouffe (speaker), D. K. Nagesha, S. K. Murthy, and L. H. Lewis, MRS Spring Meeting, San Francisco, CA, Apr 2010
  • Poster Presentation: Thermomagnetic Measurement of Magnetic Nanoparticle Size Distribution, B.D. Plouffe, R.S. DiPietro, D.K. Nagesha, L.H. Lewis, S.K. Murthy, and D. Heiman, 11th Joint MMM-Intermag Conference, Washington D.C., Jan 2010
  • Poster Presentation: Functionalization-Induced Improvement of Magnetic Properties in Fe3O4 Nanoparticles for Biomedical Applications, B.D. Plouffe, D.K. Nagesha, M. Phan, L.H. Lewis, S. Sridhar, and S.K. Murthy, Northeastern Research and Scholarship Expo, Boston, MA, Mar 2009
  • Oral Presentation: Functionalization-Induced Improvement in Magnetic Properties of Fe3O4 Nanoparticles for Biomedical Applications, Nagesha, D.K., Plouffe, B.D., Phan, M., Lewis L.H. (speaker), Sridhar, S. and Murthy, S.K., 2009 Indo-U.S. Workshop on Advanced Magnetic Materials and their Applications, Indian Institute of Technology, Mumbai, India. (invited talk), Mar 2009
  • Poster Presentation: Obtaining the Size Distribution of Magnetic Nanoparticles from Magnetization Measurements, DiPietro, R., Plouffe, B., Nagesha, D., Lewis, L. and Heiman, D., 2009 Research and Scholarship Expo, Northeastern University, Boston, MA., Mar 2009
  • Poster Presentation: Functionalization-Induced Improvement of Magnetic Properties in Fe3O4 Nanoparticles for Biomedical Applications, B.D. Plouffe, D.K. Nagesha, M. Phan, L.H. Lewis, S. Sridhar, and S.K. Murthy, 4th Annual Graduate Material Links Symposium on Interdisciplinary Graduate Research, Boston, MA, Feb 2009
  • Oral Presentation: Functionalization-Induced Improvement of Technical Magnetic Properties in Fe3O4 Nanoparticles, Nagesha, D.K. (speaker), Plouffe, B.D., Phan, M., Lewis, L.H., Sridhar, S. and Murthy, S.K., 53rd Annual Conference on Magnetism and Magnetic Materials, Austin, TX., Nov 2008
  • Poster Presentation: Microfluidic Depletion of Endothelial Cells, Smooth Muscle Cells, and Fibroblast from Heterogeneous Suspensions, B. D. Plouffe, M. Radisic, and S. K. Murthy, 2008 Northeastern Research and Scholarship Expo, Boston, MA (Outstanding Graduate Student Research Award), Mar 2008
  • Poster Presentation: Peptide-Mediated Selective Adhesion of Smooth Muscle Cells and Endothelial Cells in Shear Flow, B. D. Milica Radisic, and S. K. Murthy, 2007 Methods in Bioengineering Conference, Cambridge, MA, Jul 2007
  • Oral Presentation: Peptide-Mediated Selective Adhesion of Smooth Muscle Cells and Endothelial Cells in Shear Flow, B. D. Plouffe (speaker), M. Radisic, and S.K. Murthy, 2007 Graduate Material Links Intercollegiate Symposium on Interdisciplinary Graduate Research, Boston, MA, Feb 2007

Publications

  • Fundamentals and Application of Magnetic Particles in Biological Cell Separation (Invited Review), B.D. Plouffe, S.K. Murthy, and L.H. Lewis, Reports on Progress in Physics, V.78, P.016601 (2015)
  • Perspective on Microfluidic Cell Separation: A Solved Problem? (Invited Perpectives Article), B.D. Plouffe and S.K. Murthy, Analytical Chemistry, V.86, P.11481–11488 (2014)
  • Clinically Relevant Microfluidic Magnetophoretic Isolation of Rare-Cell Populations for Diagnostic and Therapeutic Monitoring Applications, B.D. Plouffe, M. Mahalanabis, L.H. Lewis, C.M. Klapperich, and S.K. Murthy, Analytical Chemistry, V.84, P.1336–1344 (2012)
  • Computational Design Optimization for Microfluidic Magnetophoresis, B.D. Plouffe, L.H. Lewis, and S.K. Murthy, Biomicrofluidics, V.5, P.013413 (2011)
  • Thermomagnetic determination of Fe3O4 magnetic nanoparticle diameters for biomedical applications, B.D. Plouffe, D.K. Nagesha, R.S. DiPietro, S. Sridhar, D. Heiman, S.K. Murthy, and L.H. Lewis, Journal of Magnetism and Magnetic Materials, V.323, P.2310-2317 (2011)
  • Design and Validation of an Endothelial Progenitor Cell Capture Chip and its Application in Patients with Pulmonary Hypertension, B.D. Plouffe (co-first author), G. Hansmann (co-first author), A. Hatch, A. von Gise, H. Sallmon, R.T. Zamanian, and S.K. Murthy, Journal of Molecular Medicine, V.89, P.971-983 (2011)
  • Microfluidic Cell Separation: Applications and Challenges in Tissue Engineering, B.D. Plouffe, J.V. Green, and S.K. Murthy, in Microfluidics, BioMEMS, and Medical Microsystems VIII, edited by H. Becker and W. Wang (Proc. SPIE, V.7593, Bellingham, WA) (invited contribution), P.75930P (2010)
  • Controlled Cellular Capture and Release of Cardiac Fibroblasts using Peptide-Modified Alginate Gels in Microfluidic Channels, B.D. Plouffe, M.A. Brown, R.K. Iyer. M. Radistic, and S.K. Murthy, Lab on a Chip, V.9, P.1507-1510 (2009)
  • Functionalization-Induced improvement in magnetic properties of Fe3O4 nanoparticles for biomedical applications, D.K. Nagesha, B.D. Plouffe, M.Phan, L.H. Lewis, S. Sridhar, and S.K. Murthy, Journal of Applied Physics, V.105, P.07B317 (2009)
  • Development of Microfluidics as Endothelial Progenitor Cell Capture Technology for Cardiovascular Tissue Engineering and Diagnostic Medicine, B.D. Plouffe, T. Kniazeva, J.E. Mayer, Jr., S. K. Murthy, and V.L. Sales, FASEB Journal, V.23, P.3309-3314 (2009)
  • Microfluidic Depletion of Endothelial Cells, Smooth Muscle Cells, and Fibroblasts from Heterogeneous Suspensions, B.D. Plouffe, M. Radisic, and S.K. Murthy, Lab on a Chip, V.8, P.462-472 (2008)
  • Peptide-Mediated Selective Adhesion of Smooth Muscle Cells and Endothelial Cells in Shear Flow, B.D. Plouffe, D.N. Njoka, J. Harris, J. Liao, N.K. Horick, M. Radisic, and S.K. Murthy, Langmuir, V.23, P.5050-5055 (2007)