Brendan Flynn

Brendan Flynn

E-mail:
Department: Mechanical & Industrial Engineering
Advisor: Jeffrey Ruberti

Collaborators: Charles Di Marzio, Jeffrey Ruberti

Biography

Hometown: New Orleans, LA

B.S. in Mechanical Engineering from Mississippi State University, 2006

Co-op experience with United Space Alliance at Johnson Space Center, Houston, TX

Projects

• Determination of the sensitivity of collagen fibril formation to static and oscillatory strains
• Collagen Single Fibril Mechanochemistry

Presentations

• Label-Free Quantification of Collagen Fibril Degradation Using DIC Microscopy, Flynn, B., Ruberti, J., and DiMarzio, C., Summer Bioengineering Conference, Lake Tahoe, CA., Jun 2009

Publications

• Molecular mechanochemistry: low force switch slows enzymatic cleavage of human type I collagen monomer, Camp RJ, Liles M, Beale J, Saeidi N, Flynn BP, Moore E, Murthy SK, Ruberti JW, Journal of the American Chemical Society, V.133 (11), P.4073 (2011)
• Probing collagen/enzyme mechanochemistry in native tissue with dynamic, enzyme-induced creep, Zareian R, Church KP, Saeidi N, Flynn BP, Beale JW, Ruberti JW, Langmuir, V.26, P.9917 (2010)
• Mechanical strain stabilizes reconstituted collagen fibrils against enzymatic degradation by mammalian collagenase matrix metalloproteinase 8 (MMP-8), Flynn BP, Bhole AP, Saeidi N, Liles M, Dimarzio CA, Ruberti JW, PLoS ONE, V.5(8), P.e12337 (2010)
• Mechanical strain enhances the survivability of collagen networks in the presence of collagenase: Implications for load-bearing matrix growth and stability, Bhole, A., Flynn, B.P., Liles, M., Saeidi, N., Ruberti, J. W., Philosophical transactions of the royal society A, V.In print, P. (2009)