Implantable Nanoparticles Doped Brachytherapy Spacers for Synergistic Combinatorial Chemo-radiation Therapy in Prostate Cancer

Student: Jodi Belz
Department: Bioengineering
Advisor: Sri Sridhar

Abstract

I use a nanoparticle based platforms for a control dual-release localized delivery of therapeutics in conjunction with radiation therapy in prostate cancer. This new approach involves the fabrication of inert spacers doped with nanoparticles encapsulating anti cancer drugs and fluorophores. The use of nanoparticles in fabricating brachytherapy spacers provides a sustained release depot of drug delivering chemotherapeutic drugs at the target site locally, resulting in local radio-sensitization of the prostate with the use of lower radiation doses and thereby leading to less rectal toxicity.