Development of Dual-Targeted Liposomes for Delivery of Nucleic Acid

Student: Bobby Riehle
Department: Pharmaceutical Sciences
Advisor: Vladimir Torchilin

Abstract

A novel cationic lipid based system for potential improved delivery of siRNA and DNA has been designed. Liposomes are modified with the cell surface targeting moieties Folic acid (FA) and Transferrin (TF). Many human cancers over-express FA and TF receptors and are therefore good targets for drug delivery. The cellular association of these co-targeted liposomes to human cancer cells is drastically increased as compared to plain liposomes, due to what appears to be a synergistic effect of the two moieties.